Loss of tissue and organ function is a characteristic of aging, and such changes have been attributed to decreases in stem cell function. Given the relationship between reduced stem cell activity, loss of tissue homeostasis, and aging, several key questions emerge. Is loss of tissue homeostasis due to 1) a decrease in stem cell number… Read More

Organismal aging is inextricably linked to altered metabolism at all levels- from changes in the levels of extrinsic, systemic factors (ex. hormones, insulin/Insulin-like growth factors) to decreased efficiency of cellular organelles, such as mitochondria.  Guided by our interest in the biology of aging, we are exploring whether pathways that regulate longevity act autonomously, within stem… Read More

Stem cell behavior, including the decision between self-renewal and the onset of differentiation, is influenced by the surrounding environment, or niche, in which stem cells reside.  The size and number of niches within a tissue must be tightly regulated to provide for an adequate number of stem and progenitor cells to maintain tissue homeostasis. However,… Read More