Original Research

R. Sênos Demarco, B.S. Uyemura, D.L. Jones. EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis. Cell Rep. 2020;30(4):1101-1116.e5. doi:10.1016/j.celrep.2019.12.086

R. Sênos Demarco, D.L. Jones. Mitochondrial fission regulates germ cell differentiation by suppressing ROS-mediated activation of Epidermal Growth Factor Signaling in the Drosophila larval testis. Sci Rep. 2019;9(1):19695. Published 2019 Dec 23. doi:10.1038/s41598-019-55728-0

R. Sênos-Demarco, B. S. Uyemura,  C. D’Alterio, and D. L. Jones. (2019). Mitochondrial fusion regulates lipid homeostasis and stem cell maintenance in the Drosophila testis. Nature Cell Biology, 21(6), 710–720. https://doi.org/10.1038/s41556-019-0332-3

Loza-Coll, C.C. Petrossian, M. L. Boyle, and D. L. Jones.  2019. Heterochromatin Protein 1 (HP1) inhibits stem cell proliferation induced by ectopic activation of the Jak/STAT pathway in the Drosophila testis.  Exp. Cell Res. 2019 Apr 15;377(1-2):1-9. doi: 10.1016/j.yexcr.2019.02.024. Epub 2019 Feb 25.

A.M. Salazar, M. Resnik-Docampo. M. Ulgerait, R. I. Clark, M. Shirasu-Hiza, D. L. Jones, and D. W Walker.  2018. Intestinal Snakeskin limits microbial dysbiosis during aging and promotes longevity.  iScience. Nov 30; 9:229-243. doi: 10.1016/j.isci.2018.10.022. Epub 2018 Oct 24. PMID:30419503.

M. Resnik-Docampo, V. Sauer, J.M. Schinaman, R.I. Clark, D.W. Walker, and D.L. Jones. 2018. Keeping it tight: The relationship between bacterial dysbiosis, septate junctions, and the intestinal barrier in Drosophila. Fly. doi: 10.1080/19336934.2018.1441651. Epub 2018 Mar 06.

M. Miranda, H. Christofk, D.L. Jones, W.E. Lowry. 2017. Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle. Journal of Investigative Dermatology. doi: 10.1016/j.jid.2017.10.021. Epub ahead of print.

C. L. Koehler, G. A. Perkins, M. H. Ellisman, and D. L. Jones. 2017. Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging. The Journal of Cell Biology. doi: 10.1083/jcb.201610036. Epub 2017 Jun 29.

L. P. Resende, M. E. Truong, A. Gomez, and D. L. Jones. 2017. Intestinal stem cell ablation reveals differential requirements for survival in response to chemical challenge. Developmental Biology. 424(1): 10-17.

M. Resnik-Docampo, C. L. Koehler, R. Clark, J.M. Schinaman, V. Sauer, C. D’Alterio, D. Wong, S. Lewis, Y. Wu, E. Stefani, D. Walker, and D. L. Jones. 2016. Tricellular junctions regulate intestinal stem cell behavior to maintain homeostasis. Nature Cell Biology. 19: 52–59

A. E. Conway§ E. L. Van Nostrand§, G.A. Pratt, S. Aigner, M. L. Wilbert, B. Sundararaman, P. Freese, N. J. Lambert, S. Sathe, T. Y. Liang, A. Essex, S. Landais, C.B. Burge, D. L. Jones*, G. W. Yeo*. 2016. Enhanced CLIP uncovers IMP protein-RNA targets in human pluripotent stem cells important for cell adhesion and survival. Cell Reports. Apr 19; 15(3): 666-79. doi: 10.1016/j.celrep.2016.03.052. Epub 2016 Apr 7. § -equal contribution, *- co-corresponding.

J. P. Korzelius, S.K. Naumann, M.A. Loza-Coll, J.S.K.Chan, D. Dutta, J. Oberheim, C. Glaesser, T. Southall, A. Brand, D. L. Jones, B.A. Edgar. 2014. The Snail-family transcription factor escargot maintains stem cell identity and suppresses differentiation in the Drosophila intestine. EMBO Journal. Oct 8. pii: e201489072.

M. Loza Coll, T. Southall, S. Sandall, A. Brand, and D.L. Jones. 2014. Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot. EMBO Journal. Nov 27. pii: e201489050.

S. Landais, C. D. Alterio, and D.L. Jones. 2014. Persistent replicative stress regulates Polycomb phenotypes and tissue homeostasis in Drosophila. Cell Reports. 7(3): 859-870.

J. Voog, S. Sandall, G. Hime, Resende, L.P.F., A. Aslanan, M. Loza-Coll, T. Hunter, M.T. Fuller, and D.L. Jones. 2014. Escargot restricts niche cell-stem cell conversion in the Drosophila testis. Cell Reports 7(3): 722-734.

J. H. Hur, S. Bahadorani, J. Graniel, C. L. Koehler, M. Ulgherait, M.Rera, D. L. Jones, and D. W. Walker. 2013. Increased food intake and longevity mediated by yeast NDI1 expression in Drosophila intestinal stem and progenitor cells. Aging. 5(9). Epub September 9.

Resende, L.P.F., Boyle, M., Tran, D. Fellner, T. & Jones, D. L. 2013. Headcase promotes cell survival and niche maintenance in the Drosophila testis. PLoS ONE. 8(7): e68026. doi:10.1371/journal.pone.0068026

H. Toledano, C. D’Alterio, M. Loza-Coll, and D.L. Jones. 2012. Dual fluorescent detection of protein and RNA in Drosophila tissues. Nature Protocols. 7: 1808-1817.

H. Toledano, C. D’Alterio, B. Czech, E. Levine, and D.L. Jones. 2012. The let-7-Imp axis regulates aging of the Drosophila testis stem cell niche. Nature. 485: 605-610.

C. Wong and D.L. Jones. 2012. Efficiency of spermatogonial dedifferentiation during aging. PLoS One. 7(3):e33635. Epub 2012 Mar 19.

M. Rera, S. Bahadorani, J. Cho, C. Koehler, M. Ulgherait, J.H. Hur, W.  S.  Ansari, T. L. Lo, Jr., D. L. Jones* & Walker, D.W.* 2011. Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. Cell Metabolism 14: 623-34. *co-corresponding authors.

L. Wang, C.J. McLeod, D.L. Jones. 2011. Regulation of adult stem cell behavior by nutrient signaling. Cell Cycle. 10(16): 2628-34. Epub 2011 Aug 15.

C. McLeod, L. Wang, C. Wong, and D. L. Jones. 2010. Stem cell dynamics in response to nutrient availability. Current Biology. 20: 1-6.

W. Mair, C.  McLeod, L. Wang, and D. L. Jones. 2010. Dietary restriction enhances germline stem cell maintenance. Aging Cell. 9(5): 916-8.

J. Voog, C. D’Alterio, and D.L. Jones. 2008. Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis. Nature. 454(7208): 1132-6.

T. Flatt, K.-J. Min, C. D’Alterio, E. Villa-Cuesta, J. Cumbers, R. Lehmann, D. L. Jones, and M. Tatar. 2008. Drosophila Germ-Line Modulation of Insulin Signaling and Lifespan. PNAS. 105(17): 6368-6373.

E.L. Beall, P.W. Lewis, M. Bell, M. Rocha, D.L. Jones, and M.R. Botchan. 2007. Pleiotropic functions of Myb- MuvB and a testis meiotic arrest complex (TMAC) regulate testis development in Drosophila.  Genes and Dev. 21: 904-919.

M. Boyle, C. Wong, M. Rocha, and D. L. Jones. 2007. Decline in self-renewal factors leads to aging of the stem cell niche in the Drosophila testis. Cell Stem Cell. 1(4): 470-478.

C. Schulz, A.A. Kiger, S.I. Tazuke, Y.M. Yamashita, L.C. Pantalena-Filho, D.L. Jones, C.G. Wood and M. T. Fuller. 2004. A mis-expression screen reveals effects of bag-of-marbles and Tgfb class signaling on the Drosophila male germ line stem cell lineage. Genetics 167:  707-723.

Y.M. Yamashita, D. L. Jones, and M.T. Fuller. 2003. Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science. 301: 1547-1550.

C.  Schulz, C. G. Wood, D. L. Jones, S. I. Tazuke, and M. T. Fuller. 2002. Signaling from germ cells mediated by the rhomboid homologue stet organizes encapsulation by somatic support cells. Development. 129 (19): 4523-4534.

B. Glise*, D. L. Jones*, and P.W. Ingham. 2002. Notch and Wingless modulate the response of cells to Hedgehog signalling in the Drosophila wing. Dev. Biol. 248: 93-106. (*-equal contribution).

A. A. Kiger*, D. L. Jones*, C. Schulz, M. B. Rogers, M.T. Fuller. 2001. Stem Cell Self-renewal specified by JAK-STAT signaling in response to a support cell cue. Science. 294:  2542-2545. (*-equal contribution)

D. L. Jones, D. A. Thompson, E. Suh-Bürgmann, M. Grace and K. Münger. 1999. Expression of the HPV E7 oncoprotein mimics but does not evoke a p53-dependent cellular DNA damage response pathway.Virology: 258, 406-414.

D. L. Jones, D. A. Thompson, and K. Münger. 1997. Destabilization of the RB tumor suppressor  protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis. Virology: 239 97-107.

D. L. Jones, R. M. Alani, and K. Münger.  1997. The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in  human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.  Genes and Development: 11 (16) 2101-2111.

D. L. Jones and K. Münger. 1997.  Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein. J. Virol.: 71 2905-2912.

Review Articles

M. Loza-Coll and D. L. JonesSimultaneous control of stemness and differentiation by the transcription factor Escargot in adult stem cells:  how can we tease them apart? 2016. Fly (Austin). Apr 2;10(2):53-9. Epub 2016 Apr 14. PMID: 27077690.

D.L. Jones and T.A. Rando. Stem Cell Aging. In “Molecular and Cellular Biology of Aging”. (J. Vijg, J. Campisi, and G. Lithgow. Eds.) Jones and Bartlett Publishers.

H. Toledano and D.L. Jones. 2015. Male Germline Stem Cell Aging. In “Stem Cell Aging”. (H. Jasper, H. Geiger Eds.) Springer Publishers. pp. 71-84.

K. Münger and D.L. Jones. 2015. HPV Carcinogenesis- An identity crisis in the Retinoblastoma Tumor Suppressor Pathway. J. Virol. 2015 Feb 11. pii: JVI.03486-14. PMID: 25673729.

R. Demarco, Eikenes, K. Heglund, and D.L. Jones. Investigating spermatogenesis in Drosophila melanogaster. Methods. 2014 Jun 15;68(1):218-27. doi: 10.1016/j.ymeth.2014.04.020. Epub 2014 May 2.

L. P. Resende and D.L. Jones. 2012. Local Signaling within stem cell niches: lesson from Drosophila. Curr. Op. in Cell Biol. Jan. 30.

D.L. Jones and T.A. Rando. 2011. Emerging models and paradigms of stem cell ageing. Nat Cell Biol. 13: 506-512.

H. Jasper and D.L. Jones. 2010. Metabolic regulation of stem cell behavior and implications for longevity. Cell Metabolism. 10: 561-565.

L. Wang and D.L. Jones. 2010. The relationship between stem cells and aging in Drosophila. Experimental Gerontology. Oct 29.

J. Voog and D.L. Jones. 2010. Stem cells and the Niche: a dynamic duo. Cell Stem Cell 6: 103-115.

D.L. Jones. 2009. Walk the (Germ) Line. Cell Metabolism. 10:  78-79.

D.L. Jones and M.T. Fuller. 2009. Stem Cell Niches. In “Essentials of Stem Cell Biology” Second Edition. (R. Lanza, H. Blau, D. Melton, M. Moore, E.D. Thomas, C. Verfaillie, I.Weissman, and M. West, Eds.)  Academic Press.

H. Toledano and D.L. Jones. 2009. Mechanisms regulating stem cell polarity and the specification of asymmetric divisions. StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.41.1, http://www.stembook.org

N. Geijsen and D.L.Jones. 2008. Seminal discoveries in regenerative medicine: contribution of the male germ line to understanding pluripotency. Human Mol. Genetics. 17:16-22.

D. L. Jones and A.J. Wagers. 2008. No place like home:  anatomy and function of the stem cell niche. Nat. Rev. Mol. Cell Biol. 9:11-21.

D. L. Jones. 2007. Aging and the germ line: where mortality and immortality meet. Stem Cell Reviews. 3(3):192-200.

M. F. Clarke, J.E. Dick, P. B. Dirks, C. J. Eaves, C. H. M. Jamieson, D.L. Jones, J. Visvader, I. L. Weissman, and G. M. Wahl. 2006. Cancer Stem Cells- Perspectives on Current Status and Future Directions:  AACR Workshop on Cancer Stem Cells.  Cancer Research 66 (19): 9339-9344.

Y.Yamashita, M.T.Fuller, and D.L.Jones*. 2005. Signaling in stem cell niches:  Lessons from the Drosophila germ line. J. Cell Science. 118, Pt.4:  665-672. *-corresponding author

Jones, D. L., Y. Yamashita, C. Schulz, and M. T. Fuller. 2004. Regulation of stem cell self-renewal versus differentiation by a stem cell niche: Lessons from the Drosophila male germ line.  In Handbook of Stem Cells. Vol. 1: Embryonic Stem Cells,  (R. Lanza, J. Gearhart, B. Hogan., D. Melton, R. Pedersen. J. Thomson, and M.West, eds.)  Academic Press. pp. 171-178.

D. L. Jones and M. T. Fuller. 2004.Stem cell niches.  In Handbook of Stem Cells.  Vol.2: Adult and Fetal Stem Cells (R.Lanza, H. Blau, D. Melton, M. Moore, E.D. Thomas, C. Verfaillie, I.Weissman, and M. West, eds.)  Academic Press. pp 59-72.

D. L. Jones. Stem Cells:  So what’s in a niche? 2001. Curr. Biol. 11:  R484-R486.

D.L. Jones and K. Münger. 1996.  Interactions of human papillomavirus E7 protein with cell cycle regulators. Sem. Canc. Biol.:  7 (6) 327-337.