Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the Epidermal Growth Factor Receptor. Martin Resnik-Docampo, Kathleen M. Cunningham, S. Mateo Ruvalcaba, Charles Choi, Vivien Sauer, D. Leanne Jones

DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging. Sophia K Lewis, Daniel Nachun, Martin G Martin, Steve Horvath, Giovanni Coppola, D Leanne Jones. Cell Mol Gastroenterol Hepatol. 2020;9(3):527-541. PMID: 31805439, PMCID: PMC7044532

EGFR signaling promotes basal autophagy for lipid homeostasis and somatic stem cell maintenance in the Drosophila testis. Sênos Demarco R, Jones DL. Autophagy. 2020 Jun;16(6):1145-1147. doi: 10.1080/15548627.2020.1739450. Epub 2020 Mar 21. PMID: 32150491

R. Sênos Demarco, B.S. Uyemura, D.L. Jones. EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis. Cell Rep. 2020;30(4):1101-1116.e5. doi:10.1016/j.celrep.2019.12.086

R. Sênos Demarco, D.L. Jones. Mitochondrial fission regulates germ cell differentiation by suppressing ROS-mediated activation of Epidermal Growth Factor Signaling in the Drosophila larval testis. Sci Rep. 2019;9(1):19695. Published 2019 Dec 23. doi:10.1038/s41598-019-55728-0

R. Sênos-Demarco, B. S. Uyemura,  C. D’Alterio, and D. L. Jones. (2019). Mitochondrial fusion regulates lipid homeostasis and stem cell maintenance in the Drosophila testis. Nature Cell Biology, 21(6), 710–720. https://doi.org/10.1038/s41556-019-0332-3

Loza-Coll, C.C. Petrossian, M. L. Boyle, and D. L. Jones.  2019. Heterochromatin Protein 1 (HP1) inhibits stem cell proliferation induced by ectopic activation of the Jak/STAT pathway in the Drosophila testis.  Exp. Cell Res. 2019 Apr 15;377(1-2):1-9. doi: 10.1016/j.yexcr.2019.02.024. Epub 2019 Feb 25.

A.M. Salazar, M. Resnik-Docampo. M. Ulgerait, R. I. Clark, M. Shirasu-Hiza, D. L. Jones, and D. W Walker.  2018. Intestinal Snakeskin limits microbial dysbiosis during aging and promotes longevity.  iScience. Nov 30; 9:229-243. doi: 10.1016/j.isci.2018.10.022. Epub 2018 Oct 24. PMID:30419503.

M. Resnik-Docampo, V. Sauer, J.M. Schinaman, R.I. Clark, D.W. Walker, and D.L. Jones. 2018. Keeping it tight: The relationship between bacterial dysbiosis, septate junctions, and the intestinal barrier in Drosophila. Fly. doi: 10.1080/19336934.2018.1441651. Epub 2018 Mar 06.

M. Miranda, H. Christofk, D.L. Jones, W.E. Lowry. 2017. Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle. Journal of Investigative Dermatology. doi: 10.1016/j.jid.2017.10.021. Epub ahead of print.

C. L. Koehler, G. A. Perkins, M. H. Ellisman, and D. L. Jones. 2017. Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging. The Journal of Cell Biology. doi: 10.1083/jcb.201610036. Epub 2017 Jun 29.

L. P. Resende, M. E. Truong, A. Gomez, and D. L. Jones. 2017. Intestinal stem cell ablation reveals differential requirements for survival in response to chemical challenge. Developmental Biology. 424(1): 10-17.

M. Resnik-Docampo, C. L. Koehler, R. Clark, J.M. Schinaman, V. Sauer, C. D’Alterio, D. Wong, S. Lewis, Y. Wu, E. Stefani, D. Walker, and D. L. Jones. 2016. Tricellular junctions regulate intestinal stem cell behavior to maintain homeostasis. Nature Cell Biology. 19: 52–59

A. E. Conway§ E. L. Van Nostrand§, G.A. Pratt, S. Aigner, M. L. Wilbert, B. Sundararaman, P. Freese, N. J. Lambert, S. Sathe, T. Y. Liang, A. Essex, S. Landais, C.B. Burge, D. L. Jones*, G. W. Yeo*. 2016.Enhanced CLIP uncovers IMP protein-RNA targets in human pluripotent stem cells important for cell adhesion and survival. Cell Reports. Apr 19; 15(3): 666-79. doi: 10.1016/j.celrep.2016.03.052. Epub 2016 Apr 7. § -equal contribution, *- co-corresponding.

J. P. Korzelius, S.K. Naumann, M.A. Loza-Coll, J.S.K.Chan, D. Dutta, J. Oberheim, C. Glaesser, T. Southall, A. Brand, D. L. Jones, B.A. Edgar. 2014. The Snail-family transcription factor escargot maintains stem cell identity and suppresses differentiation in the Drosophila intestine. EMBO Journal. Oct 8. pii: e201489072.

M. Loza Coll, T. Southall, S. Sandall, A. Brand, and D.L. Jones. 2014. Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot. EMBO Journal. Nov 27. pii: e201489050.

S. Landais, C. D. Alterio, and D.L. Jones. 2014. Persistent replicative stress regulates Polycomb phenotypes and tissue homeostasis in Drosophila. Cell Reports. 7(3): 859-870.

J. Voog, S. Sandall, G. Hime, Resende, L.P.F., A. Aslanan, M. Loza-Coll, T. Hunter, M.T. Fuller, and D.L. Jones. 2014. Escargot restricts niche cell-stem cell conversion in the Drosophila testis. Cell Reports 7(3): 722-734.

J. H. Hur, S. Bahadorani, J. Graniel, C. L. Koehler, M. Ulgherait, M.Rera, D. L. Jones, and D. W. Walker. 2013. Increased food intake and longevity mediated by yeast NDI1 expression in Drosophilaintestinal stem and progenitor cells. Aging. 5(9). Epub September 9.

Resende, L.P.F., Boyle, M., Tran, D. Fellner, T. & Jones, D. L. 2013. Headcase promotes cell survival and niche maintenance in the Drosophila testis. PLoS ONE. 8(7): e68026. doi:10.1371/journal.pone.0068026

H. Toledano, C. D’Alterio, M. Loza-Coll, and D.L. Jones. 2012. Dual fluorescent detection of protein and RNA in Drosophila tissues. Nature Protocols. 7: 1808-1817.

H. Toledano, C. D’Alterio, B. Czech, E. Levine, and D.L. Jones. 2012. The let-7-Imp axis regulates aging of the Drosophila testis stem cell niche. Nature. 485: 605-610.

C. Wong and D.L. Jones. 2012. Efficiency of spermatogonial dedifferentiation during aging. PLoS One. 7(3):e33635. Epub 2012 Mar 19.

M. Rera, S. Bahadorani, J. Cho, C. Koehler, M. Ulgherait, J.H. Hur, W.  S.  Ansari, T. L. Lo, Jr., D. L. Jones* & Walker, D.W.* 2011. Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. Cell Metabolism 14: 623-34. *co-corresponding authors.

L. Wang, C.J. McLeod, D.L. Jones. 2011. Regulation of adult stem cell behavior by nutrient signaling. Cell Cycle. 10(16): 2628-34. Epub 2011 Aug 15.

C. McLeod, L. Wang, C. Wong, and D. L. Jones. 2010. Stem cell dynamics in response to nutrient availability. Current Biology. 20: 1-6.

W. Mair, C.  McLeod, L. Wang, and D. L. Jones. 2010. Dietary restriction enhances germline stem cell maintenance. Aging Cell. 9(5): 916-8.

J. Voog, C. D’Alterio, and D.L. Jones. 2008. Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis. Nature. 454(7208): 1132-6.

T. Flatt, K.-J. Min, C. D’Alterio, E. Villa-Cuesta, J. Cumbers, R. Lehmann, D. L. Jones, and M. Tatar. 2008. Drosophila Germ-Line Modulation of Insulin Signaling and Lifespan. PNAS. 105(17): 6368-6373.

E.L. Beall, P.W. Lewis, M. Bell, M. Rocha, D.L. Jones, and M.R. Botchan. 2007. Pleiotropic functions of Myb- MuvB and a testis meiotic arrest complex (TMAC) regulate testis development in Drosophila. Genes and Dev. 21: 904-919.

M. Boyle, C. Wong, M. Rocha, and D. L. Jones. 2007. Decline in self-renewal factors leads to aging of the stem cell niche in the Drosophila testis. Cell Stem Cell. 1(4): 470-478.

DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging. Sophia K Lewis, Daniel Nachun, Martin G Martin, Steve Horvath, Giovanni Coppola, D Leanne Jones. Cell Mol Gastroenterol Hepatol. 2020;9(3):527-541. PMID: 31805439, PMCID: PMC7044532

EGFR signaling promotes basal autophagy for lipid homeostasis and somatic stem cell maintenance in the Drosophila testis. Sênos Demarco R, Jones DL. Autophagy. 2020 Jun;16(6):1145-1147. doi: 10.1080/15548627.2020.1739450. Epub 2020 Mar 21. PMID: 32150491

Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the Epidermal Growth Factor Receptor. Martin Resnik-Docampo, Kathleen M. Cunningham, S. Mateo Ruvalcaba, Charles Choi, Vivien Sauer, D. Leanne Jones

R. Sênos Demarco, B.S. Uyemura, D.L. Jones. EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis. Cell Rep. 2020;30(4):1101-1116.e5. doi:10.1016/j.celrep.2019.12.086

R. Sênos Demarco, D.L. Jones. Mitochondrial fission regulates germ cell differentiation by suppressing ROS-mediated activation of Epidermal Growth Factor Signaling in the Drosophila larval testis. Sci Rep. 2019;9(1):19695. Published 2019 Dec 23. doi:10.1038/s41598-019-55728-0

R. Sênos-Demarco, B. S. Uyemura,  C. D’Alterio, and D. L. Jones. (2019). Mitochondrial fusion regulates lipid homeostasis and stem cell maintenance in the Drosophila testis. Nature Cell Biology, 21(6), 710–720. https://doi.org/10.1038/s41556-019-0332-3

Loza-Coll, C.C. Petrossian, M. L. Boyle, and D. L. Jones.  2019. Heterochromatin Protein 1 (HP1) inhibits stem cell proliferation induced by ectopic activation of the Jak/STAT pathway in the Drosophila testis.  Exp. Cell Res. 2019 Apr 15;377(1-2):1-9. doi: 10.1016/j.yexcr.2019.02.024. Epub 2019 Feb 25.

A.M. Salazar, M. Resnik-Docampo. M. Ulgerait, R. I. Clark, M. Shirasu-Hiza, D. L. Jones, and D. W Walker.  2018. Intestinal Snakeskin limits microbial dysbiosis during aging and promotes longevity.  iScience. Nov 30; 9:229-243. doi: 10.1016/j.isci.2018.10.022. Epub 2018 Oct 24. PMID:30419503.

M. Resnik-Docampo, V. Sauer, J.M. Schinaman, R.I. Clark, D.W. Walker, and D.L. Jones. 2018. Keeping it tight: The relationship between bacterial dysbiosis, septate junctions, and the intestinal barrier in Drosophila. Fly. doi: 10.1080/19336934.2018.1441651. Epub 2018 Mar 06.

M. Miranda, H. Christofk, D.L. Jones, W.E. Lowry. 2017. Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle. Journal of Investigative Dermatology. doi: 10.1016/j.jid.2017.10.021. Epub ahead of print.

C. L. Koehler, G. A. Perkins, M. H. Ellisman, and D. L. Jones. 2017. Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging. The Journal of Cell Biology. doi: 10.1083/jcb.201610036. Epub 2017 Jun 29.

L. P. Resende, M. E. Truong, A. Gomez, and D. L. Jones. 2017. Intestinal stem cell ablation reveals differential requirements for survival in response to chemical challenge. Developmental Biology. 424(1): 10-17.

M. Resnik-Docampo, C. L. Koehler, R. Clark, J.M. Schinaman, V. Sauer, C. D’Alterio, D. Wong, S. Lewis, Y. Wu, E. Stefani, D. Walker, and D. L. Jones. 2016. Tricellular junctions regulate intestinal stem cell behavior to maintain homeostasis. Nature Cell Biology. 19: 52–59

A. E. Conway§ E. L. Van Nostrand§, G.A. Pratt, S. Aigner, M. L. Wilbert, B. Sundararaman, P. Freese, N. J. Lambert, S. Sathe, T. Y. Liang, A. Essex, S. Landais, C.B. Burge, D. L. Jones*, G. W. Yeo*. 2016.Enhanced CLIP uncovers IMP protein-RNA targets in human pluripotent stem cells important for cell adhesion and survival. Cell Reports. Apr 19; 15(3): 666-79. doi: 10.1016/j.celrep.2016.03.052. Epub 2016 Apr 7. § -equal contribution, *- co-corresponding.

J. P. Korzelius, S.K. Naumann, M.A. Loza-Coll, J.S.K.Chan, D. Dutta, J. Oberheim, C. Glaesser, T. Southall, A. Brand, D. L. Jones, B.A. Edgar. 2014. The Snail-family transcription factor escargot maintains stem cell identity and suppresses differentiation in the Drosophila intestine. EMBO Journal. Oct 8. pii: e201489072.

M. Loza Coll, T. Southall, S. Sandall, A. Brand, and D.L. Jones. 2014. Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot. EMBO Journal. Nov 27. pii: e201489050.

S. Landais, C. D. Alterio, and D.L. Jones. 2014. Persistent replicative stress regulates Polycomb phenotypes and tissue homeostasis in Drosophila. Cell Reports. 7(3): 859-870.

J. Voog, S. Sandall, G. Hime, Resende, L.P.F., A. Aslanan, M. Loza-Coll, T. Hunter, M.T. Fuller, and D.L. Jones. 2014. Escargot restricts niche cell-stem cell conversion in the Drosophila testis. Cell Reports 7(3): 722-734.

J. H. Hur, S. Bahadorani, J. Graniel, C. L. Koehler, M. Ulgherait, M.Rera, D. L. Jones, and D. W. Walker. 2013. Increased food intake and longevity mediated by yeast NDI1 expression in Drosophilaintestinal stem and progenitor cells. Aging. 5(9). Epub September 9.

Resende, L.P.F., Boyle, M., Tran, D. Fellner, T. & Jones, D. L. 2013. Headcase promotes cell survival and niche maintenance in the Drosophila testis. PLoS ONE. 8(7): e68026. doi:10.1371/journal.pone.0068026

H. Toledano, C. D’Alterio, M. Loza-Coll, and D.L. Jones. 2012. Dual fluorescent detection of protein and RNA in Drosophila tissues. Nature Protocols. 7: 1808-1817.

H. Toledano, C. D’Alterio, B. Czech, E. Levine, and D.L. Jones. 2012. The let-7-Imp axis regulates aging of the Drosophila testis stem cell niche. Nature. 485: 605-610.

C. Wong and D.L. Jones. 2012. Efficiency of spermatogonial dedifferentiation during aging. PLoS One. 7(3):e33635. Epub 2012 Mar 19.

M. Rera, S. Bahadorani, J. Cho, C. Koehler, M. Ulgherait, J.H. Hur, W.  S.  Ansari, T. L. Lo, Jr., D. L. Jones* & Walker, D.W.* 2011. Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. Cell Metabolism 14: 623-34. *co-corresponding authors.

L. Wang, C.J. McLeod, D.L. Jones. 2011. Regulation of adult stem cell behavior by nutrient signaling. Cell Cycle. 10(16): 2628-34. Epub 2011 Aug 15.

C. McLeod, L. Wang, C. Wong, and D. L. Jones. 2010. Stem cell dynamics in response to nutrient availability. Current Biology. 20: 1-6.

W. Mair, C.  McLeod, L. Wang, and D. L. Jones. 2010. Dietary restriction enhances germline stem cell maintenance. Aging Cell. 9(5): 916-8.

J. Voog, C. D’Alterio, and D.L. Jones. 2008. Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis. Nature. 454(7208): 1132-6.

T. Flatt, K.-J. Min, C. D’Alterio, E. Villa-Cuesta, J. Cumbers, R. Lehmann, D. L. Jones, and M. Tatar. 2008. Drosophila Germ-Line Modulation of Insulin Signaling and Lifespan. PNAS. 105(17): 6368-6373.

E.L. Beall, P.W. Lewis, M. Bell, M. Rocha, D.L. Jones, and M.R. Botchan. 2007. Pleiotropic functions of Myb- MuvB and a testis meiotic arrest complex (TMAC) regulate testis development in Drosophila. Genes and Dev. 21: 904-919.

M. Boyle, C. Wong, M. Rocha, and D. L. Jones. 2007. Decline in self-renewal factors leads to aging of the stem cell niche in the Drosophila testis. Cell Stem Cell. 1(4): 470-478.

C. Schulz, A.A. Kiger, S.I. Tazuke, Y.M. Yamashita, L.C. Pantalena-Filho, D.L. Jones, C.G. Wood and M. T. Fuller. 2004. A mis-expression screen reveals effects of bag-of-marbles and Tgfb class signaling on the Drosophila male germ line stem cell lineage. Genetics 167:  707-723.

Y.M. Yamashita, D. L. Jones, and M.T. Fuller. 2003. Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science. 301: 1547-1550.

C.  Schulz, C. G. Wood, D. L. Jones, S. I. Tazuke, and M. T. Fuller. 2002. Signaling from germ cells mediated by the rhomboid homologue stet organizes encapsulation by somatic support cells. Development. 129 (19): 4523-4534.

B. Glise*, D. L. Jones*, and P.W. Ingham. 2002. Notch and Wingless modulate the response of cells to Hedgehog signalling in the Drosophila wing. Dev. Biol. 248: 93-106. (*-equal contribution).

A. A. Kiger*, D. L. Jones*, C. Schulz, M. B. Rogers, M.T. Fuller. 2001. Stem Cell Self-renewal specified by JAK-STAT signaling in response to a support cell cue. Science. 294:  2542-2545. (*-equal contribution)

D. L. Jones, D. A. Thompson, E. Suh-Bürgmann, M. Grace and K. Münger. 1999. Expression of the HPV E7 oncoprotein mimics but does not evoke a p53-dependent cellular DNA damage response pathway.Virology: 258, 406-414.

D. L. Jones, D. A. Thompson, and K. Münger. 1997. Destabilization of the RB tumor suppressor  protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis. Virology: 239 97-107.

D. L. Jones, R. M. Alani, and K. Münger.  1997. The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in  human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.  Genes and Development: 11 (16) 2101-2111.

D. L. Jones and K. Münger. 1997.  Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein. J. Virol.: 71 2905-2912.